Michelle Riehle, PhD
Assistant Professor
Locations
- Microbiology & Immunology
BSB B2920
Contact Information
Education
Research Experience
- Anopheles
- Evolution, Molecular
- Genetic Variation
- Host-Parasite Interactions
- Immunity, Innate
- Insect Vectors
- Malaria, Falciparum
Educational Expertise
- Evolution, Molecular
- Genetics
- Microbiology
Research Interests
Our main areas of scientific investigation revolve around understanding differential susceptibility to infection with malaria parasites in the mosquito vector population.
We are taking an approach grounded in genetics to understand how natural variation affects a mosquito’s ability to be infected with Plasmodium parasites. Our current focus is on querying the non-coding genome; specifically enhancers, small RNAs and long non-coding RNAs. We complement our genetics approaches with functional investigations employing microbiological, biochemical, cell biological and molecular biology approaches.
We are also interested in how the prokaryotic and micro eukaryotic members of the mosquito microbiome influence to the mosquito immune response and how specific bacterial or microeukaryotic taxa affect mosquito gene expression and the innate immune response to infection with Plasmodium falciparum.
All of our work leverages approaches across many scientific disciplines including genetics, molecular biology, microbiology, cell biology, and computational biology to address important outstanding questions in malaria transmission and human health.
Publications
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(Eggleston H, Njoya K, Anderson CE, Holm I, Eiglmeier K, Liang J, Sharakhov IV, Vernick KD, Riehle MM.) Parasit Vectors. 2022 Dec 13;15(1):465 PMID: 36514125 PMCID: PMC9749150 SCOPUS ID: 2-s2.0-85143791043 12/14/2022
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(Bukhari T, Aimanianda V, Bischoff E, Brito-Fravallo E, Eiglmeier K, Riehle MM, Vernick KD, Mitri C.) Sci Rep. 2022 Apr 15;12(1):6315 PMID: 35428783 PMCID: PMC9012835 SCOPUS ID: 2-s2.0-85128387936 04/17/2022
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(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Jun 09;11(1):12553 PMID: 34108534 PMCID: PMC8190266 SCOPUS ID: 2-s2.0-85107408524 06/11/2021
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(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Sci Rep. 2021 Mar 19;11(1):6458 PMID: 33742030 PMCID: PMC7979810 SCOPUS ID: 2-s2.0-85102850695 03/21/2021
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(Xue AT, Schrider DR, Kern AD, Ag1000g Consortium.) Mol Biol Evol. 2021 Mar 09;38(3):1168-1183 PMID: 33022051 PMCID: PMC7947845 SCOPUS ID: 2-s2.0-85102911117 10/07/2020
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(Farley EJ, Eggleston H, Riehle MM.) Insects. 2021 Feb 22;12(2) PMID: 33671692 PMCID: PMC7926655 03/07/2021
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(Holm I, Nardini L, Pain A, Bischoff E, Anderson CE, Zongo S, Guelbeogo WM, Sagnon N, Gohl DM, Nowling RJ, Vernick KD, Riehle MM.) Front Genet. 2021;12:785934 PMID: 35082832 PMCID: PMC8784733 01/28/2022
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(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85102850695 12/01/2021
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(Vantaux A, Riehle MM, Piv E, Farley EJ, Chy S, Kim S, Corbett AG, Fehrman RL, Pepey A, Eiglmeier K, Lek D, Siv S, Mueller I, Vernick KD, Witkowski B.) Scientific Reports. December 2021;11(1) SCOPUS ID: 2-s2.0-85107408524 12/01/2021
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(Cuesta EB, Coulibaly B, Bukhari T, Eiglmeier K, Kone R, Coulibaly MB, Zongo S, Barry M, Gneme A, Guelbeogo WM, Beavogui AH, Traore SF, Sagnon N, Vernick KD, Riehle MM.) Front Microbiol. 2021;12:635772 PMID: 34054746 PMCID: PMC8153677 06/01/2021
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(Grau-Bové X, Lucas E, Pipini D, Rippon E, van 鈥榯 Hof AE, Constant E, Dadzie S, Egyir-Yawson A, Essandoh J, Chabi J, Djogbénou L, Harding NJ, Miles A, Kwiatkowski DP, Donnelly MJ, Weetman D, Amaya-Romero JE, Ayala D, Battey CJ, Bejon P, Besansky NJ, Burt A, Cano J, Caputo B, Constant E, Costantini C, Coulibaly B, della Torre A, Diabaté A, Dinis J, Donnelly MJ, Drury E, Edouardo J, Elissa N, Essandoh J, Fontaine MC, Godfray CHJ, Hahn MW, Harding NJ, Henrichs C, Hubbart C, Isaacs AT, Jawara M, Jeffreys AE, Jyothi D, Kamali M, Kern AD, Clarkson CS, Lawniczak MKN, Le Goff G, Lucas E, Malangone C, Mawejje HD, Mbogo C, Mead D, Midega J, Miles A, Nwakanma DC, O鈥橪oughlin S, Pinto J, Riehle MM, Robert V, Rockett KA, Rohatgi KR, Rowlands K, Schrider DR, Sharakhov I, Simpson V, Stalker J, Troco AD, Vernick KD, Weetman D, Bradley J.) PLoS Genetics. 21 January 2021;17(1) SCOPUS ID: 2-s2.0-85099805834 01/21/2021
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(Anopheles gambiae 1000 Genomes Consortium.) Genome Res. 2020 Oct;30(10):1533-1546 PMID: 32989001 PMCID: PMC7605271 SCOPUS ID: 2-s2.0-85092682445 09/30/2020