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Research Bench Lab

Microbiology & Immunology

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Tecle Laboratory

Tecle Laboratory

Location
Microbiology & Immunology
Office: TBRC C3970, Lab: TBRC C3673

General Interests
Epithelial Immunity, Intracellular Pathogens, Purine Metabolism, Glycobiology

View Eillen Tecle Bio

BSB2_renovation_research

Tecle Lab Research Areas

Research Areas

The broad goal of the Tecle lab’s research program is to investigate the mechanisms that regulate innate epithelial immune responses against intracellular pathogens. To do this, we use infection of the Caenorhabditis elegans intestine by its natural microsporidian pathogen as a model system. The transparent body of C. elegans allows for direct visualization of its twenty non-renewable intestinal cells during infection, and the lack of professional immune cells in C. elegans allows one to focus on epithelial defense specifically. Our current research focus is two-fold. First, we are investigating the role of purine recycling in the host response to microsporidia infection. Second, we are exploring the host glycome to identify factors required for microsporidia infection.

(Tecle E, Troemel ER.) Exp Suppl. 2022;114:115-136 PMID: 35544001 PMCID: PMC9208714 05/12/2022
(Tecle E, Chhan CB, Franklin L, Underwood RS, Hanna-Rose W, Troemel ER.) PLoS Pathog. 2021 Apr;17(4):e1009350 PMID: 33878133 PMCID: PMC8087013 04/21/2021
(Sowa JN, Jiang H, Somasundaram L, Tecle E, Xu G, Wang D, Troemel ER.) J Virol. 2020 Jan 06;94(2) PMID: 31619561 PMCID: PMC6955277 10/18/2019
(Tecle E, Reynoso HS, Wang R, Gagneux P.) J Biol Chem. 2019 Aug 02;294(31):11910-11919 PMID: 31201275 PMCID: PMC6682739 06/16/2019
(Saied-Santiago K, Townley RA, Attonito JD, da Cunha DS, Díaz-Balzac CA, Tecle E, Bülow HE.) Genetics. 2017 Aug;206(4):1951-1967 PMID: 28576860 PMCID: PMC5560800 06/04/2017
(Tecle E, Gagneux P.) Mol Reprod Dev. 2015 Sep;82(9):635-50 PMID: 26061344 PMCID: PMC4744710 06/11/2015
(Díaz-Balzac CA, Lázaro-Peña MI, Tecle E, Gomez N, Bülow HE.) G3 (Bethesda). 2014 Aug 05;4(10):1859-70 PMID: 25098771 PMCID: PMC4199693 08/08/2014
(Salzberg Y, Díaz-Balzac CA, Ramirez-Suarez NJ, Attreed M, Tecle E, Desbois M, Kaprielian Z, Bülow HE.) Cell. 2013 Oct 10;155(2):308-20 PMID: 24120132 PMCID: PMC3881433 10/15/2013
(Tecle E, Diaz-Balzac CA, Bülow HE.) G3 (Bethesda). 2013 Mar;3(3):541-52 PMID: 23451335 PMCID: PMC3583460 03/02/2013