Terhune Laboratory

Location
Microbiology & Immunology
TBRC C2890

General Interests
Human Cytomegalovirus Host-Cell Protein Interactions During Infection

Research Areas

Our research focuses on determining the molecular functions of human cytomegalovirus (HCMV) proteins during infection and disease. HCMV is a member of the beta-herpesvirus family of viruses which includes HHV-6 and 7. Infection occurs upon exposure to virus-containing body fluids, is life-long and generally asymptomatic in healthy children and adults. However, during pregnancy, HCMV infection may result in congenital birth defects including hearing loss and neurological damage. In immunologically immature or compromised children and adults, infection often results in life threatening diseases. And, increasing evidence suggestions that persistent life-long HCMV infection is associated with numerous chronic diseases including atherosclerosis, immuno-senescence, cancer and possibly Alzheimer’s Disease.

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Current Members

Andrew Sukowaty

Research Technologist, Terhune Lab

asukowaty@mcw.edu

Christopher Monti

M3 Student

cmonti@mcw.edu

Eva Rodriguez

Graduate Student

emrodriguez@mcw.edu

Sameya Aurna

Graduate Student

saurna@mcw.edu

Suzette Rosas, PhD

Postdoctoral Fellow, Terhune Lab

srosas@mcw.edu

(Womack JA, Shah V, Audi SH, Terhune SS, Dash RK.) Bioinform Adv. 2024;4(1):vbae023 PMID: 38456125 PMCID: PMC10918630 SCOPUS ID: 2-s2.0-85187381144 03/08/2024
(Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) mBio. 2023 Dec 19;14(6):e0225123 PMID: 37966250 PMCID: PMC10746155 SCOPUS ID: 2-s2.0-85183165409 11/15/2023
(O'Brien BS, Mokry RL, Schumacher ML, Rosas-Rogers S, Terhune SS, Ebert AD.) J Virol. 2023 Oct 31;97(10):e0069623 PMID: 37796129 PMCID: PMC10653813 SCOPUS ID: 2-s2.0-85175819477 10/05/2023
(Shah V, Womack J, Zamora AE, Terhune SS, Dash RK.) Annu Int Conf IEEE Eng Med Biol Soc. 2023 Jul;2023:1-5 PMID: 38083755 SCOPUS ID: 2-s2.0-85179638579 12/12/2023
(Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F.) PLoS Pathog. 2023 Jun;19(6):e1011185 PMID: 37289831 PMCID: PMC10284425 SCOPUS ID: 2-s2.0-85163920856 06/08/2023
(Adelman JW, Rosas-Rogers S, Schumacher ML, Mokry RL, Terhune SS, Ebert AD.) bioRxiv. 2023 Mar 06 PMID: 36945635 PMCID: PMC10028818 03/23/2023
(Forte E, Li M, Ayaloglu Butun F, Hu Q, Borst EM, Schipma MJ, Piunti A, Shilatifard A, Terhune SS, Abecassis M, Meier JL, Hummel M.) Microbiol Spectr. 2023 Feb 14;11(1):e0314422 PMID: 36645269 PMCID: PMC9927211 SCOPUS ID: 2-s2.0-85148092420 01/17/2023
(Shah V, Womack J, Zamora AE, Terhune SS, Dash RK.) ArXiv. 2023 Feb 08 PMID: 36798455 PMCID: PMC9934731 02/18/2023
(Zarrella K, Longmire P, Zeltzer S, Collins-McMillen D, Hancock M, Buehler J, Reitsma JM, Terhune SS, Nelson JA, Goodrum F.) bioRxiv. 2023 Feb 07 PMID: 36798153 PMCID: PMC9934528 02/18/2023
(Monti CE, Mokry RL, Schumacher ML, Dash RK, Terhune SS.) Proc Natl Acad Sci U S A. 2022 Aug 30;119(35):e2201787119 PMID: 35994667 PMCID: PMC9437303 SCOPUS ID: 2-s2.0-85136192098 08/23/2022
(Mokry RL, O'Brien BS, Adelman JW, Rosas S, Schumacher ML, Ebert AD, Terhune SS.) J Virol. 2022 Jul 27;96(14):e0012622 PMID: 35862705 PMCID: PMC9327702 SCOPUS ID: 2-s2.0-85135227929 07/22/2022
(O'Brien BS, Mokry RL, Schumacher ML, Pulakanti K, Rao S, Terhune SS, Ebert AD.) iScience. 2022 Apr 15;25(4):104098 PMID: 35391828 PMCID: PMC8980761 04/09/2022
(Albright ER, Morrison K, Ranganathan P, Carter DM, Nishikiori M, Lee JH, Slayton MD, Ahlquist P, Terhune SS, Kalejta RF.) Proc Natl Acad Sci U S A. 2022 Apr 05;119(14):e2122174119 PMID: 35344424 PMCID: PMC9169081 SCOPUS ID: 2-s2.0-85127264685 03/29/2022
(Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S.) Methods Mol Biol. 2022;2463:195-204 PMID: 35344176 SCOPUS ID: 2-s2.0-85127680170 03/29/2022
(Jung Y, Kraikivski P, Shafiekhani S, Terhune SS, Dash RK.) NPJ Syst Biol Appl. 2021 Dec 09;7(1):46 PMID: 34887439 PMCID: PMC8660825 SCOPUS ID: 2-s2.0-85121043614 12/11/2021
(Dixon KJ, Siebert JR, Wang D, Abel AM, Johnson KE, Riese MJ, Terhune SS, Tarakanova VL, Thakar MS, Malarkannan S.) Mol Immunol. 2021 Sep;137:94-104 PMID: 34242922 SCOPUS ID: 2-s2.0-85109126048 07/10/2021
(Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S.) Cells. 2021 Jul 31;10(8) PMID: 34440725 PMCID: PMC8393955 SCOPUS ID: 2-s2.0-85115044374 08/28/2021
(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. 2020 Dec 15;11(6) PMID: 33323506 PMCID: PMC7773989 SCOPUS ID: 2-s2.0-85098068781 12/17/2020
(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
(Terhune SS, Jung Y, Cataldo KM, Dash RK.) PLoS Comput Biol. 2020 Apr;16(4):e1007733 PMID: 32251461 PMCID: PMC7162553 SCOPUS ID: 2-s2.0-85083620688 04/07/2020
(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2020 Mar 17;94(7) PMID: 32184335 PMCID: PMC7081901 SCOPUS ID: 2-s2.0-85082001595 03/19/2020
(Mokry RL, Schumacher ML, Hogg N, Terhune SS.) mBio. November-December 2020;11(6):1-25 SCOPUS ID: 2-s2.0-85098068781 11/01/2020
(Sison SL, O'Brien BS, Johnson AJ, Seminary ER, Terhune SS, Ebert AD.) J Virol. 2019 Sep 01;93(17) PMID: 31217241 PMCID: PMC6694809 SCOPUS ID: 2-s2.0-85071355135 06/21/2019
(Rak MA, Buehler J, Zeltzer S, Reitsma J, Molina B, Terhune S, Goodrum F.) J Virol. 2018 Oct 15;92(20) PMID: 30089695 PMCID: PMC6158428 SCOPUS ID: 2-s2.0-85052151483 08/10/2018
(Forte E, Swaminathan S, Schroeder MW, Kim JY, Terhune SS, Hummel M.) mBio. 2018 Sep 11;9(5) PMID: 30206173 PMCID: PMC6134100 SCOPUS ID: 2-s2.0-85055538738 09/13/2018

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